多疾病相关人中性粒细胞弹性蛋白酶抑制剂研究进展

张捷, 谭俊杰, 李医明

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (21) : 1873-1878.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (21) : 1873-1878. DOI: 10.11669/cpj.2017.21.001
综述

多疾病相关人中性粒细胞弹性蛋白酶抑制剂研究进展

  • 张捷, 谭俊杰, 李医明*
作者信息 +

Research Progress of Human Neutrophil Elastase Inhibitors and Their Application in Diverse Diseases

  • ZHANG Jie, TAN Jun-jie, LI Yi-ming*
Author information +
文章历史 +

摘要

为全面了解人中性粒细胞弹性蛋白酶抑制剂(human neutrophil elastase inhibitor, HNEI)的研究现状和临床应用前景, 查阅2011年及以后发现的HNEI及人中性粒细胞弹性蛋白酶(human neutrophil elastase, HNE)参与肺部外疾病的文献, 并进行归纳整理。结果发现, 2011年以来出现了许多选择性高、抑制作用强的HNEI。HNE参与许多疾病的发生, 除过去报道较多的传染性和炎症性肺部疾病外, 还与局部缺血再灌注损伤、类风湿性关节炎、自身免疫性糖尿病、肾炎、癌症的发生发展等疾病有关。开发高效低毒的HNE抑制剂已成为治疗相关疾病的重要方向。

Abstract

To comprehensively understand the research status of human neutrophil elastase inhibitors (HNEI) and their clinical application prospect, the papers about novel HNEI discovered since 2011 and diseases related to human neutrophil elastase (HNE) in addition to pulmonary diseases were summarized. The results showed that a lot of highly selective and potent HNE inhibitors have been discovered since 2011. HNE participates in the development of many diseases. In addition to the infectious and inflammatory pulmonary diseases reported in the past, it is also associated with ischemia-reperfusion injury, rheumatoid arthritis, autoimmune diabetes, nephritis, cancer and other diseases. The development of novel HNEI with high potency and low toxicity has been an important direction for HNE-related diseases.

关键词

人中性粒细胞弹性蛋白酶 / 人中性粒细胞弹性蛋白酶抑制剂 / 西维来司钠 / 合成抑制剂 / 天然抑制剂 / 肺部疾病

Key words

human neutrophil elastase / human neutrophil elastase inhibitor / sivelestat sodium / synthetic inhibitor / natural inhibitor / pulmonary disease

引用本文

导出引用
张捷, 谭俊杰, 李医明. 多疾病相关人中性粒细胞弹性蛋白酶抑制剂研究进展[J]. 中国药学杂志, 2017, 52(21): 1873-1878 https://doi.org/10.11669/cpj.2017.21.001
ZHANG Jie, TAN Jun-jie, LI Yi-ming. Research Progress of Human Neutrophil Elastase Inhibitors and Their Application in Diverse Diseases[J]. Chinese Pharmaceutical Journal, 2017, 52(21): 1873-1878 https://doi.org/10.11669/cpj.2017.21.001
中图分类号: R97   

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基金

国家自然科学基金面上资助项目(81673570);上海市科技创新行动计划资助项目(14401901800)
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